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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2F
All Species:
38.79
Human Site:
Y660
Identified Species:
85.33
UniProt:
P51841
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51841
NP_001513.2
1108
124822
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
E
F
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001098846
1108
125126
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
E
F
V
Dog
Lupus familis
XP_538138
1108
124925
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
E
F
A
Cat
Felis silvestris
Mouse
Mus musculus
Q5SDA5
1108
124407
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
E
F
I
Rat
Rattus norvegicus
P51842
1108
124393
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
E
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506097
1100
119406
Y681
D
L
I
Q
G
I
R
Y
L
H
H
R
G
F
P
Chicken
Gallus gallus
XP_417281
1078
121075
Y632
D
L
I
K
G
I
R
Y
L
H
H
R
D
F
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103165
1107
124634
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
N
V
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
Y641
D
I
L
K
G
M
I
Y
L
H
D
S
E
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
Y673
D
V
A
K
G
L
E
Y
L
H
K
T
F
L
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
Y682
D
L
V
K
G
I
V
Y
L
H
S
S
E
I
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.5
91.4
N.A.
89.9
89.8
N.A.
51.3
60.7
N.A.
61.9
N.A.
31.5
N.A.
29.5
32.5
Protein Similarity:
100
N.A.
98.1
94.7
N.A.
93.7
93.5
N.A.
67.2
75
N.A.
75.9
N.A.
48.6
N.A.
47.9
50.4
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
66.6
73.3
N.A.
80
N.A.
53.3
N.A.
40
53.3
P-Site Similarity:
100
N.A.
100
93.3
N.A.
100
100
N.A.
86.6
93.3
N.A.
80
N.A.
73.3
N.A.
60
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
100
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
64
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
64
0
% F
% Gly:
0
0
0
0
100
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
100
73
0
0
0
0
% H
% Ile:
0
10
73
0
0
28
10
0
0
0
0
0
0
19
28
% I
% Lys:
0
0
0
91
0
0
55
0
0
0
10
0
0
0
10
% K
% Leu:
0
82
10
0
0
10
0
0
100
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
64
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
19
0
0
0
0
73
0
0
10
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
10
19
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% T
% Val:
0
10
10
0
0
0
10
0
0
0
0
0
0
10
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _